专利详情

专利名称	Salt and polymorph of pyrazolopyrimidinone compound, and pharmaceutical composition containing the same, preparation method and use thereof
申请号	US201214238790	专利类型	US
公开（公告）号	US9527849(B2)	公开（授权）日	2016.12.27
申请（专利权）人	中国科学院上海药物研究所	发明（设计）人	Li Jianfeng;Tian Guanghui;Wang Zhen;Suo Jin;Jiang Xiangrui;Liu Zheng;Yang Xiaojun;Xie Zhu;Zhao Xianguo;Zhu Weiliang;Jiang Hualiang;Shen Jingshan
主分类号	C07D487/04	IPC主分类号	C07D487/04;A61K31/519;A61P15/10;A61P13/10;A61P9/10;A61P9/04;A61P13/12;A61P11/06;A61P29/00;A61P27/06;A61P9/12
专利有效期	Salt and polymorph of pyrazolopyrimidinone compound, and pharmaceutical composition containing the same, preparation method and use thereof 至Salt and polymorph of pyrazolopyrimidinone compound, and pharmaceutical composition containing the same, preparation method and use thereof	法律状态
说明书摘要	The present invention relates to new salts of pyrazolopyrimidinone represented by formula (I), and pharmaceutically acceptable polymorph, solvate, hydrate, dehydrate, co-crystallization, anhydrous, or amorphous form thereof, the pharmaceutical compositions, and a pharmaceutical unit dosage form containing the same, wherein x represents organic or inorganic acids, preferable maleic acid, succinic acid, methanesulfonic acid, hydrochloric acid, etc. The invention further relates to co-crystals or complexes of compounds of pyrazolopyrimidinone and pharmaceutical compositions containing the same. The present invention also relates to a process for the preparation, use thereof and pharmaceutical preparation containing the salts or crystalline forms.;