专利详情

专利名称	Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof
申请号	US201414580509	专利类型	US
公开（公告）号	US9452220(B2)	公开（授权）日	2016.09.27
申请（专利权）人	中国科学院广州生物医药与健康研究院	发明（设计）人	Zhang Yanmei;Ding Ke;Liao Jinxi;Wang Yican;Chen Panyu
主分类号	C07D239/94	IPC主分类号	C07D239/94;C07D403/12;C07D403/14;C07D405/12;C07D405/14;A61K47/48
专利有效期	Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof 至Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof	法律状态
说明书摘要	The present invention discloses coupling compounds of a structure as shown in Formula I, II or III formed by connecting NSAID anti-inflammatory and analgesic drugs and EGFR inhibitors by ester bonds or pharmaceutically acceptable salts or stereoisomers thereof or prodrug molecules thereof:;where R is a NSAID anti-inflammatory and analgesic drug. In the present invention, the coupling compounds obtained by coupling NSAID anti-inflammatory and analgesic drugs with EGFR inhibitors have excellent therapeutic effects of tumors and provide new drugs for clinic treatment options.