欢迎来到喀斯玛汇智科技服务平台

服务热线: 010-82648522

首页 > 专利推荐 > 专利详情

Method for increasing the efficiency of inducing pluripotent stem cells

  • 申请号:US201213808596
  • 专利类型:US
  • 申请(专利权)人:中国科学院广州生物医药与健康研究院
  • 公开(公开)号:US9163217(B2)
  • 公开(公开)日:2015.10.20
  • 法律状态:
  • 出售价格: 面议
  • 立即咨询

专利详情

专利名称 Method for increasing the efficiency of inducing pluripotent stem cells
申请号 US201213808596 专利类型 US
公开(公告)号 US9163217(B2) 公开(授权)日 2015.10.20
申请(专利权)人 中国科学院广州生物医药与健康研究院 发明(设计)人 Pei Duanqing;Wang Tao
主分类号 C12N15/00 IPC主分类号 C12N15/00;C12N5/0775;C12N5/074
专利有效期 Method for increasing the efficiency of inducing pluripotent stem cells 至Method for increasing the efficiency of inducing pluripotent stem cells 法律状态
说明书摘要 The present invention relates to a method for increasing the efficiency of inducing pluripotent stem cells by utilizing genes Jhdm1b and Jhdm1a that modify histone. By utilizing Jhdm1b, Jhdm1a, and a stem cell inducing factor, the present invention increases the efficiency of inducing pluripotent stem cells and increases the quality of induced pluripotent stem cells. The stem cell inducing factor is a combination of Oct4 and Klf4, or a combination of Sox2, Oct4, and Klf4, or a combination of Oct4 and Sox2, and Oct4 alone. The method further comprises exposing the cells to vitamin C, which further increases the efficiency of inducing pluripotent stem cells as compared with the case where no vitamin C is used. By using less stem cell reducing factors, the method of the present invention reduces the potential carcinogenicity, obtains a high inducing efficiency, and provides high-quality induced pluripotent stem cells capable of germ-line transmission.

交易流程

  • 01 选取所需
    专利
  • 02 确认专利
    可交易
  • 03 签订合同
  • 04 上报材料
  • 05 确认变更
    成功
  • 06 支付尾款
  • 07 交付证书

平台保障

1、源头对接,价格透明

2、平台验证,实名审核

3、合同监控,代办手续

4、专员跟进,交易保障

  • 用户留言
暂时还没有用户留言

求购专利

专利交易流程

  • 01 选取所需专利
  • 02 确认专利可交易
  • 03 签订合同
  • 04 上报材料
  • 05 确认变更成功
  • 06 支付尾款
  • 07 交付证书
官方客服(周一至周五:8:30-17:30) 010-82648522