专利详情

专利名称	ISOQUINOLINE -1,3,4-TRIONE, THE SYNTHETIC METHOD AND THE USE THEREOF
申请号	EP20040738186	专利类型	EP
公开（公告）号	EP1640367(B1)	公开（授权）日	2011.02.09
申请（专利权）人	中国科学院上海药物研究所	发明（设计）人	NAN, FAJUN;LI, JIA;CHEN, YIHUA;ZHANG, YAHUI;GU, MIN;ZHANG, HUAJIE
主分类号	A61P25/28	IPC主分类号	A61P25/28;C07D217/04;A61P25/00;C07D217/24;C07D417/04
专利有效期	ISOQUINOLINE -1,3,4-TRIONE, THE SYNTHETIC METHOD AND THE USE THEREOF 至ISOQUINOLINE -1,3,4-TRIONE, THE SYNTHETIC METHOD AND THE USE THEREOF	法律状态
说明书摘要	The invention relates to various substituted isoquinoline-1,3,4-trione, the synthetic method thereof and the use for treating neurodegenerative diseases, especially as the medicine for Alzhermer''s disease, apoplexy and brain ischemic injuries. The compound is represented by the following structure formula: Wherein substituents R 1 can be one, two or three groups optionally selected from the group consisting of H; alkyl; hydroxyl; alkyl substituted by the groups including halogen, alkoxyl or hydroxyl; alkoxyl or alkylamino substituted by the groups including halogen, alkoxyl or hydroxyl; C 2 -C 6 alkenyl substituted by oxygen or amine; C 3 -C 6 cycloalkyl; substituted aryl; benzyl; alkanoyl; alkanoyl substituted by the groups including halogen, alkoxyl or hydroxyl; C 2 -C 6 enoyl; C 3 -C 6 cycloalkanoyl; tert -butoxycarbonyl; benzoyl; benzoyl substituted by one, two or three groups including alkylamino; benzylacyl; benzylacyl substituted by one, two or three groups including alkylamino; thienoyl; adamantylcarbonyl; mandeloyl; alkoxyl; alkylamino; cycloalkoxyl; cycloalkylamino; amino; acylamino; alkyloxycarbonyl; cycloalkoxycarbonyl; alkanoylxy; alkanoylamino; cycloalkyanoylxy; cycloalkanoylamino; ureido; urenylene; alkanoyl; nitro; carboxyl; R 2 is H; alkyl; alkyl or C 1 -C 4 cycloalkyl substituted by the groups including halogen, alkoxyl or hydroxyl; C 2 -C 6 alkenyl; aryl; substituted aryl; X is H, CH 2 , NH, O, or S; Y is CH, or N.