专利详情

专利名称	SULFATED DERIVATIVE OF GASTRODIA ELATA POLYSACCHARIDE, PREPARATION METHOD AND USE THEREOF
申请号	EP20090817166	专利类型	EP
公开（公告）号	EP2338917(B1)	公开（授权）日	2014.03.05
申请（专利权）人	中国科学院上海药物研究所	发明（设计）人	DING, KAN;QIU, HONG
主分类号	A61K31/737	IPC主分类号	A61K31/737;A61K36/8988;A61P35/04;C08B37/00
专利有效期	SULFATED DERIVATIVE OF GASTRODIA ELATA POLYSACCHARIDE, PREPARATION METHOD AND USE THEREOF 至SULFATED DERIVATIVE OF GASTRODIA ELATA POLYSACCHARIDE, PREPARATION METHOD AND USE THEREOF	法律状态
说明书摘要	The present invention discloses a sulfated derivative of polysaccharide extracted from gastrodia elata BL., the preparation method thereof and the use thereof in preparing antineoplastic medicaments, wherein, the gastrodia elata polysaccharide has the following structure: ± - D - GLc ?? p - 1 [ ?’ 4 - ± - D - Glc ?? p - ( 1 ] x ?“ 6 - { [ ?’ 4 ) - ± - D - Glc ?? p - ( 1 ] y ?’ 4 - ± - D - Glc ?? p - ( 1 ?’ } n - wherein, x and y are each an integer, and x + y = 16, "n" is and integer, and the mean molecular weight of the polysaccharide from gastrodia elata is estimated as 2.8 x 10 5 , the specific rotation of the polysaccharide is +95° in a 0.5 mg/mL aqueous solution thereof; the sulfated position is mainly at 6-hydroxy of the gastrodia elata polysaccharide, with mean molecular weight of 6.5 × 10 4 and a specific rotation of +150.0° in a 0.5 mg/mL aqueous solution thereof. In vivo and in vitro experiments indicate that the sulfated derivative of gastrodia elata polysaccharide can inhibit the tumor growth by suppressing the expression ofi Id1 to inhibit angiogenesis, and therefore has an obvious antitumor activity, and shows almost nontoxicity to endothelial cells, thereby having a good prospect of being developed into antineoplastic medicaments.