专利详情

专利名称	2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF
申请号	EP20130746724	专利类型	EP
公开（公告）号	EP2813495(B1)	公开（授权）日	2016.09.28
申请（专利权）人	中国科学院上海药物研究所	发明（设计）人	YANG, CHUNHAO;MIAO, ZEHONG;DING, JIAN;WANG, MENG;HE, JINXUE;TAN, CUN;CHEN, YI
主分类号	C07D307/81	IPC主分类号	C07D307/81;A61P29/00;A61P35/00;C07D405/04;C07D405/12
专利有效期	2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF 至2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF	法律状态
说明书摘要	Provided in the present invention are a 2-arylbenzofuran-7-formamide compound as shown in general formula I or a pharmacologically or physiologically acceptable salt thereof, a preparation method thereof and use thereof in preparing anti-tumour drugs, wherein R 1 and R 2 are each independently hydrogen, straight or branched chained C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl or saturated 5- or 6-membered heterocyclyl containing oxygen or nitrogen; or R 1 and R 2 together with N form an unsubstituted or substituted saturated 5- or 6-membered heterocyclyl containing at least one heteroatom, wherein the heteroatom is O, N and S, the substituent is a methyl on N; R 3 is a hydrogen atom or a chlorine atom; R 4 is a hydrogen atom or a fluorine atom; X is CH, CF or N; and Y is CH, CF or N.