专利详情

专利名称	Rapamycin carbonic ester analogues, pharmaceutical compositions, preparations and uses thereof
申请号	US200913119700	专利类型	US
公开（公告）号	US8455510(B2)	公开（授权）日	2013.06.04
申请（专利权）人	中国科学院上海药物研究所	发明（设计）人	NAN FAJUNDING JIANZUO JIANPINGYU LINQIANMENG LINGHUAZHANG YANGMINGYANG NAGU MI
主分类号	C07D498/18	IPC主分类号	C07D498/18;A61K31/436;A61P35/00
专利有效期	Rapamycin carbonic ester analogues, pharmaceutical compositions, preparations and uses thereof 至Rapamycin carbonic ester analogues, pharmaceutical compositions, preparations and uses thereof	法律状态
说明书摘要	Rapalogs of formula I, pharmaceutically acceptable salts, pharmaceutical compositions, and preparation methods and uses thereof. The rapalogs have the structure of formula I and can be used as an anti-tumor medicament. Comparing with rapamycin, the rapalogs of the present invention exhibit enhanced water solubility, and improved pharmacological and pharmacokinetic properties by introducing a hydrophilic and polar group such as a hydroxyl.