专利详情

专利名称	Amide compounds, their pharmaceutical compositions, their preparation method and their uses
申请号	US200913123455	专利类型	US
公开（公告）号	US8410094(B2)	公开（授权）日	2013.04.02
申请（专利权）人	中国科学院上海药物研究所	发明（设计）人	LONG YAQIUFAN XINGFENG DONGZHICHEN LICHEN RENHA
主分类号	C07D451/04	IPC主分类号	C07D451/04;A61K31/46
专利有效期	Amide compounds, their pharmaceutical compositions, their preparation method and their uses 至Amide compounds, their pharmaceutical compositions, their preparation method and their uses	法律状态
说明书摘要	The present invention pertains to the field of pharmaceutical chemistry and discloses 8-(3-aminopropyl)-3-exo-8-azabicyclo[3.2.1]octane-3-amino amide compounds represented by formula I, the pharmaceutical compositions, the preparation method and the use thereof. Such compounds or pharmaceutically acceptable salts thereof can be used as an antagonist of CCR5 in preparing medicaments for treating diseases mediated by CCR5, particularly HIV infection, asthma, rheumatoid arthritis, autoimmune diseases and chronic obstructive pulmonary diseases (COPD).