专利详情

专利名称	THE USE OF SUCCINATE DERIVATIVE ESTERS FOR THE TREATMENT OF DEMENTIA
申请号	EP20030782083	专利类型	EP
公开（公告）号	EP1582209(B1)	公开（授权）日	2012.09.19
申请（专利权）人	中国科学院上海药物研究所	发明（设计）人	ZHANG JIANJUNSHI JIANGONGWANG YAFANGZHANG DANGAO MEIYANG YONGCHUNHUANG SHENGYAN
主分类号	A61K31/222	IPC主分类号	A61K31/222;A61K31/194;A61K31/7012;A61K31/7028;A61P25/28
专利有效期	THE USE OF SUCCINATE DERIVATIVE ESTERS FOR THE TREATMENT OF DEMENTIA 至THE USE OF SUCCINATE DERIVATIVE ESTERS FOR THE TREATMENT OF DEMENTIA	法律状态
说明书摘要	The use of extract form Wangla (coeloglossum viride (L) Hartm. Var. Bracteatum (Willd.) Richter), succinate derivative esters, and a derivative and pharmaceutical acceptable salts thereof, for the manufacture of a pharmaceutical preparation for the treatment of dementia, particularly for the treatment of Alzheimer'' disease and Vascular dementia. Through Animal experiment, it has been demonstrated that, succinate derivative esters can improve learning and memory ability in dementia rats induced by scopolamine and cyclohexenyl imine; improve learning and memory ability in dementia rats induced by beta-amyloid; improve learning and memory ability in dementia rats induced by permanent ligation of bilateral carotid; and improve memory ability of normal animals. It has the advantage of high activity, low toxicity and no inhibition to cholinesterase.