专利详情

专利名称	Pyrazolopyramidinone derivatives, their preparation and their use
申请号	EP20100171901	专利类型	EP
公开（公告）号	EP2253632(B1)	公开（授权）日	2012.05.23
申请（专利权）人	中国科学院上海药物研究所	发明（设计）人	TIAN GUANGHUILAI SHUNANWANG ZHENZHU YICHEN XINJIANJI YURONGZHANG JINFENGJIN WEIXILV HEPINGLIU JINPINGWANG WEIJI RUYUNSHEN JINGSHA
主分类号	C07D487/04	IPC主分类号	C07D487/04;A61K31/519;A61P15/10
专利有效期	Pyrazolopyramidinone derivatives, their preparation and their use 至Pyrazolopyramidinone derivatives, their preparation and their use	法律状态
说明书摘要	The invention discloses a series of pyrazolopyrimidinone derivatives, which have the following chemical structure, their preparation methods and use, It has been proved by pharmacological experiment that the said pyrazolopyrimidinone derivatives have high inhibitory activity against PDE5, and parts of them have a much stronger potency against PDE5 than against PDE6. Most of the compounds show low toxicity. The pyrazolopyrimidinone derivatives can be used in clinics for the palliative or curative treatment of symptoms or diseases relating to cardiovascular system, urinary system, especially for the palliative or curative treatment of erectile dysfunction.