专利详情

专利名称	Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof
申请号	GB20120011226	专利类型	GB
公开（公告）号	GB201211226(D0)	公开（授权）日	2012.08.08
申请（专利权）人	中国科学院上海药物研究所	发明（设计）人
主分类号		IPC主分类号
专利有效期	Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof 至Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof	法律状态
说明书摘要	A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises rigid membrane, push layer, drug layer, separating layer and aesthetic coating is disclosed. The rigid membrane contains semi-permeable polymer, hole-forming agent and/or plasticizer and has one or more delivery orifices on one end. The push layer comprises expanding material, permeation-promoter, binder, colorant and lubricant. The drug layer contains pharmaceutical active component, hydrophilic polymer carrier, permeation-promoter, colorant, lubricant and antistatic agent. The separating layer is between the inner surface of the rigid membrane and core comprised of drug layer and push layer and contains hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows increased release at initial stage and keeps constant release at late stage.