专利详情

专利名称	Production process for 16-dehydropregnenoneol and its analogs
申请号	US20050561164	专利类型	US
公开（公告）号	US2006166955	公开（授权）日	2006.07.27
申请（专利权）人	中国科学院上海有机化学研究所	发明（设计）人	TIAN WEISHENG (CN);XU XIN (CN);LIU SHANSHAN (CN);SHEN JUNWEI (CN);WU XIUJING (CN)
主分类号	A61K31/56	IPC主分类号	A61K31/56;C07J5/00;C07J7/00;C07J71/00
专利有效期	Production process for 16-dehydropregnenoneol and its analogs 至Production process for 16-dehydropregnenoneol and its analogs	法律状态
说明书摘要	The present invention relates to a clean process for the degradation of steroidal sapogenin to produce 16-dehydropregnenolone and its analogs. The pure or the crude pseudo steroidal sapogenin, derived from steroidal sapogenin, dissolved in organic solvent, reacts with hydrogen peroxide with or without metal compound and acid as catalyst, and the crude products directly go through elimination and hydrolization in the presence of base to give 16-Dehydropregnenolone or its analog, accompanied with the other product 4R(or S)-methyl-5-hydroxy-pentate, which is converted to 4R(or S)-methyl-delta-pentyl lactone after acidification and extraction from the water layer. This technology improved the utilizing degree of steroidal sapogenin, improved the yield, and cleared up the chromium pollution in the former technique. In a word, the method disclosed in this invention is more suitable for manufacture.