专利详情

专利名称	Method of imaging with fluorescent microspheres
申请号	US20070441894	专利类型	US
公开（公告）号	US8460638(B2)	公开（授权）日	2013.06.11
申请（专利权）人	中国科学院过程工程研究所	发明（设计）人	MA GUANGHUISU ZHIGUOWEI WEIWANG LIANYANWEI QIAN
主分类号	A61B5/00	IPC主分类号	A61B5/00
专利有效期	Method of imaging with fluorescent microspheres 至Method of imaging with fluorescent microspheres	法律状态
说明书摘要	A method of fluorescence imaging is disclosed that uses a non-labeled fluorescent microsphere comprising a primary amine polymer, wherein the microsphere does not contain an additional fluorescent substance, and wherein at least one primary amine group in the primary amine polymer has the structure of -N=R-, in which R is a residue after the reaction of an aldehyde-type cross-linking substance, and the other primary amine groups have the structure of -NH2. The fluorescence color of the microspheres can be adjusted by selecting different aldehyde-type cross-linking substances or combinations, and the fluorescence intensity of the microspheres can be controlled not only by the addition of the aldehyde-type cross-linking substances and the time of the cross-linking reaction, but also by adjusting the diameters of the microspheres.